{"id":1069,"date":"2002-03-19T14:46:23","date_gmt":"2002-03-19T13:46:23","guid":{"rendered":"https:\/\/www.francecoag.org\/?post_type=publications_science&#038;p=1069"},"modified":"2025-03-21T15:43:16","modified_gmt":"2025-03-21T14:43:16","slug":"chambost-h-et-al-what-factors-influence-the-age-at-diagnosis-of-hemophilia-results-of-the-french-hemophilia-cohort","status":"publish","type":"publications_science","link":"https:\/\/www.francecoag.org\/en\/publications_science\/chambost-h-et-al-what-factors-influence-the-age-at-diagnosis-of-hemophilia-results-of-the-french-hemophilia-cohort\/","title":{"rendered":"Chambost H et al\u00a0: What Factors Influence the Age at Diagnosis of Hemophilia? Results of the French Hemophilia Cohort"},"content":{"rendered":"<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12378196\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/12378196\/<\/a><\/p>\n<header id=\"heading\" class=\"heading\">\n<div id=\"full-view-heading\" class=\"full-view\">\n<ul id=\"full-view-identifiers\" class=\"identifiers\">\n<li><span class=\"identifier pubmed\"> <span class=\"id-label\"> PMID: <\/span> <strong class=\"current-id\" title=\"PubMed ID\">12378196<\/strong> <\/span><\/li>\n<li><span class=\"identifier doi\"> <span class=\"id-label\"> DOI: <\/span> <a class=\"id-link\" href=\"https:\/\/doi.org\/10.1067\/mpd.2002.128115\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\"> 10.1067\/mpd.2002.128115 <\/a> <\/span><\/li>\n<\/ul>\n<\/div>\n<\/header>\n<div id=\"abstract\" class=\"abstract\">\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\"> Objective: <\/strong> The diagnosis of hemophilia was reported as delayed in historic studies. We therefore investigated this issue to provide current epidemiologic data in a large series of patients.<\/p>\n<p><strong class=\"sub-title\"> Study design: <\/strong> The French cohort provided the opportunity to investigate the age at diagnosis and the circumstances of diagnosis in 599 individuals with hemophilia born between 1980 and 1994. The type and the severity of hemophilia, the family history, and the period of birth were analyzed as potential modifying factors.<\/p>\n<p><strong class=\"sub-title\"> Results: <\/strong> The median age at diagnosis was 7.7 months, with significant differences among subgroups: 5.8 months in severe hemophilia, 9.0 months in moderate forms, 28.6 months in mild forms, 0.4 months in the case of hemophilic brothers, and 10.1 months in de novo hemophilia, which accounted for 55.3% of cases. In severe forms we observed a trend for earlier diagnosis throughout 3 consecutive periods from 1980 to 1994. Of bleeding episode, testing due to family history, or routine testing, bleeding was the main circumstance of diagnosis (59.9%).<\/p>\n<p><strong class=\"sub-title\"> Conclusions: <\/strong> Diagnosis was made earlier than in historic series, but it remained somewhat delayed. Early diagnosis will require efforts in the fields of genetic counseling and specific diagnosis of early bleeding, even without family history, because of the high incidence of de novo hemophilia.<\/p>\n<\/div>\n<\/div>\n","protected":false},"parent":0,"template":"","keyword":[],"class_list":["post-1069","publications_science","type-publications_science","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Chambost H et al\u00a0: What Factors Influence the Age at Diagnosis of Hemophilia? Results of the French Hemophilia Cohort - FranceCoag<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.francecoag.org\/en\/publications_science\/chambost-h-et-al-what-factors-influence-the-age-at-diagnosis-of-hemophilia-results-of-the-french-hemophilia-cohort\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Chambost H et al\u00a0: What Factors Influence the Age at Diagnosis of Hemophilia? Results of the French Hemophilia Cohort - FranceCoag\" \/>\n<meta property=\"og:description\" content=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/12378196\/ PMID: 12378196 DOI: 10.1067\/mpd.2002.128115 Abstract Objective: The diagnosis of hemophilia was reported as delayed in historic studies. We therefore [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.francecoag.org\/en\/publications_science\/chambost-h-et-al-what-factors-influence-the-age-at-diagnosis-of-hemophilia-results-of-the-french-hemophilia-cohort\/\" \/>\n<meta property=\"og:site_name\" content=\"FranceCoag\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-21T14:43:16+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/chambost-h-et-al-what-factors-influence-the-age-at-diagnosis-of-hemophilia-results-of-the-french-hemophilia-cohort\\\/\",\"url\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/chambost-h-et-al-what-factors-influence-the-age-at-diagnosis-of-hemophilia-results-of-the-french-hemophilia-cohort\\\/\",\"name\":\"Chambost H et al\u00a0: What Factors Influence the Age at Diagnosis of Hemophilia? 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