{"id":1049,"date":"2019-03-19T14:40:40","date_gmt":"2019-03-19T13:40:40","guid":{"rendered":"https:\/\/www.francecoag.org\/?post_type=publications_science&#038;p=1049"},"modified":"2025-03-19T14:53:09","modified_gmt":"2025-03-19T13:53:09","slug":"iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries","status":"publish","type":"publications_science","link":"https:\/\/www.francecoag.org\/en\/publications_science\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\/","title":{"rendered":"Iorio A et al : Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries"},"content":{"rendered":"<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31499529\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/31499529\/<\/a><\/p>\n<header id=\"heading\" class=\"heading\">\n<div id=\"full-view-heading\" class=\"full-view\">\n<ul id=\"full-view-identifiers\" class=\"identifiers\">\n<li><span class=\"identifier pubmed\"> <span class=\"id-label\"> PMID: <\/span> <strong class=\"current-id\" title=\"PubMed ID\">31499529<\/strong> <\/span><\/li>\n<li><span class=\"identifier doi\"> <span class=\"id-label\"> DOI: <\/span> <a class=\"id-link\" href=\"https:\/\/doi.org\/10.7326\/m19-1208\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\"> 10.7326\/M19-1208 <\/a> <\/span><\/li>\n<\/ul>\n<\/div>\n<\/header>\n<div id=\"abstract\" class=\"abstract\">\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\"> Background: <\/strong> The large observed variability in hemophilia prevalence prevents robust estimation of burden of disease.<\/p>\n<p><strong class=\"sub-title\"> Objective: <\/strong> To estimate the prevalence and prevalence at birth of hemophilia and the associated life expectancy disadvantage.<\/p>\n<p><strong class=\"sub-title\"> Design: <\/strong> Random-effects meta-analysis of registry data.<\/p>\n<p><strong class=\"sub-title\"> Setting: <\/strong> Australia, Canada, France, Italy, New Zealand, and the United Kingdom.<\/p>\n<p><strong class=\"sub-title\"> Participants: <\/strong> Male patients with hemophilia A or B.<\/p>\n<p><strong class=\"sub-title\"> Measurements: <\/strong> Prevalence of hemophilia as a proportion of cases to the male population, prevalence of hemophilia at birth as a proportion of cases to live male births by year of birth, life expectancy disadvantage as a 1 &#8211; ratio of prevalence to prevalence at birth, and expected number of patients worldwide based on prevalence in high-income countries and prevalence at birth.<\/p>\n<p><strong class=\"sub-title\"> Results: <\/strong> Prevalence (per 100 000 males) is 17.1 cases for all severities of hemophilia A, 6.0 cases for severe hemophilia A, 3.8 cases for all severities of hemophilia B, and 1.1 cases for severe hemophilia B. Prevalence at birth (per 100 000 males) is 24.6 cases for all severities of hemophilia A, 9.5 cases for severe hemophilia A, 5.0 cases for all severities of hemophilia B, and 1.5 cases for severe hemophilia B. The life expectancy disadvantage for high-income countries is 30% for hemophilia A, 37% for severe hemophilia A, 24% for hemophilia B, and 27% for severe hemophilia B. The expected number of patients with hemophilia worldwide is 1 125 000, of whom 418 000 should have severe hemophilia.<\/p>\n<p><strong class=\"sub-title\"> Limitation: <\/strong> Details were insufficient to adjust for comorbid conditions and ethnicity.<\/p>\n<p><strong class=\"sub-title\"> Conclusion: <\/strong> The prevalence of hemophilia is higher than previously estimated. Patients with hemophilia still have a life expectancy disadvantage. Establishing prevalence at birth is a milestone toward assessing years of life lost, years of life with disability, and burden of disease.<\/p>\n<p><strong class=\"sub-title\"> Primary funding source: <\/strong> None.<\/p>\n<\/div>\n<\/div>\n","protected":false},"parent":0,"template":"","keyword":[],"class_list":["post-1049","publications_science","type-publications_science","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Iorio A et al : Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries - FranceCoag<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.francecoag.org\/en\/publications_science\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Iorio A et al : Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries - FranceCoag\" \/>\n<meta property=\"og:description\" content=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31499529\/ PMID: 31499529 DOI: 10.7326\/M19-1208 Abstract Background: The large observed variability in hemophilia prevalence prevents robust estimation of burden of [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.francecoag.org\/en\/publications_science\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\/\" \/>\n<meta property=\"og:site_name\" content=\"FranceCoag\" \/>\n<meta property=\"article:modified_time\" content=\"2025-03-19T13:53:09+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\\\/\",\"url\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\\\/\",\"name\":\"Iorio A et al : Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries - FranceCoag\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#website\"},\"datePublished\":\"2019-03-19T13:40:40+00:00\",\"dateModified\":\"2025-03-19T13:53:09+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications scientifiques\",\"item\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Iorio A et al : Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/\",\"name\":\"FranceCoag\",\"description\":\"La cohorte FranceCoag accompagne plus de 10.000 patients atteints d\u2019une maladie h\u00e9morragique\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#organization\",\"name\":\"FranceCoag\",\"url\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.francecoag.org\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/logo-france-COAG-1.png\",\"contentUrl\":\"https:\\\/\\\/www.francecoag.org\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/logo-france-COAG-1.png\",\"width\":600,\"height\":260,\"caption\":\"FranceCoag\"},\"image\":{\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Iorio A et al : Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries - FranceCoag","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.francecoag.org\/en\/publications_science\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\/","og_locale":"en_US","og_type":"article","og_title":"Iorio A et al : Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries - FranceCoag","og_description":"https:\/\/pubmed.ncbi.nlm.nih.gov\/31499529\/ PMID: 31499529 DOI: 10.7326\/M19-1208 Abstract Background: The large observed variability in hemophilia prevalence prevents robust estimation of burden of [&hellip;]","og_url":"https:\/\/www.francecoag.org\/en\/publications_science\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\/","og_site_name":"FranceCoag","article_modified_time":"2025-03-19T13:53:09+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.francecoag.org\/en\/publications_science\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\/","url":"https:\/\/www.francecoag.org\/en\/publications_science\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\/","name":"Iorio A et al : Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries - FranceCoag","isPartOf":{"@id":"https:\/\/www.francecoag.org\/en\/#website"},"datePublished":"2019-03-19T13:40:40+00:00","dateModified":"2025-03-19T13:53:09+00:00","breadcrumb":{"@id":"https:\/\/www.francecoag.org\/en\/publications_science\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.francecoag.org\/en\/publications_science\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.francecoag.org\/en\/publications_science\/iorio-a-et-al-establishing-the-prevalence-and-prevalence-at-birth-of-hemophilia-in-males-a-meta-analytic-approach-using-national-registries\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.francecoag.org\/en\/"},{"@type":"ListItem","position":2,"name":"Publications scientifiques","item":"https:\/\/www.francecoag.org\/en\/publications_science\/"},{"@type":"ListItem","position":3,"name":"Iorio A et al : Establishing the Prevalence and Prevalence at Birth of Hemophilia in Males: A Meta-analytic Approach Using National Registries"}]},{"@type":"WebSite","@id":"https:\/\/www.francecoag.org\/en\/#website","url":"https:\/\/www.francecoag.org\/en\/","name":"FranceCoag","description":"La cohorte FranceCoag accompagne plus de 10.000 patients atteints d\u2019une maladie h\u00e9morragique","publisher":{"@id":"https:\/\/www.francecoag.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.francecoag.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.francecoag.org\/en\/#organization","name":"FranceCoag","url":"https:\/\/www.francecoag.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.francecoag.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.francecoag.org\/wp-content\/uploads\/2023\/12\/logo-france-COAG-1.png","contentUrl":"https:\/\/www.francecoag.org\/wp-content\/uploads\/2023\/12\/logo-france-COAG-1.png","width":600,"height":260,"caption":"FranceCoag"},"image":{"@id":"https:\/\/www.francecoag.org\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/publications_science\/1049","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/publications_science"}],"about":[{"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/types\/publications_science"}],"version-history":[{"count":1,"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/publications_science\/1049\/revisions"}],"predecessor-version":[{"id":1050,"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/publications_science\/1049\/revisions\/1050"}],"wp:attachment":[{"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/media?parent=1049"}],"wp:term":[{"taxonomy":"keyword","embeddable":true,"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/keyword?post=1049"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}