{"id":1047,"date":"2020-12-19T14:40:05","date_gmt":"2020-12-19T13:40:05","guid":{"rendered":"https:\/\/www.francecoag.org\/?post_type=publications_science&#038;p=1047"},"modified":"2026-02-12T15:33:33","modified_gmt":"2026-02-12T14:33:33","slug":"rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency","status":"publish","type":"publications_science","link":"https:\/\/www.francecoag.org\/en\/publications_science\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\/","title":{"rendered":"Rugeri L et al : Gynecological and obstetric outcome in the French cohort of women with Factor XIII deficiency"},"content":{"rendered":"<p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32360976\/\">https:\/\/pubmed.ncbi.nlm.nih.gov\/32360976\/<\/a><\/p>\n<header id=\"heading\" class=\"heading\">\n<div id=\"full-view-heading\" class=\"full-view\">\n<ul id=\"full-view-identifiers\" class=\"identifiers\">\n<li><span class=\"identifier pubmed\"> <span class=\"id-label\"> PMID: <\/span> <strong class=\"current-id\" title=\"PubMed ID\">32360976<\/strong> <\/span><\/li>\n<li><span class=\"identifier doi\"> <span class=\"id-label\"> DOI: <\/span> <a class=\"id-link\" href=\"https:\/\/doi.org\/10.1016\/j.thromres.2020.04.010\" target=\"_blank\" rel=\"noopener\" data-ga-category=\"full_text\" data-ga-action=\"DOI\"> 10.1016\/j.thromres.2020.04.010 <\/a> <\/span><\/li>\n<\/ul>\n<\/div>\n<\/header>\n<div id=\"abstract\" class=\"abstract\">\n<h2 class=\"title\">Abstract<\/h2>\n<div id=\"eng-abstract\" class=\"abstract-content selected\">\n<p><strong class=\"sub-title\"> Introduction: <\/strong> Congenital factor XIII deficiency is a very rare bleeding disorder affecting 33 patients in France. Besides its role in fibrin clot stabilization, factor XIII is involved in placental attachment. Fetal miscarriages represent a frequent and concerning issue for these patients. The aim of the present study was to describe clinical characteristics of women presenting severe congenital FXIII deficiency in France, to focus on gynecological and obstetrical events, and to report the management of these rare situations.<\/p>\n<p><strong class=\"sub-title\"> Methods: <\/strong> We conducted a retrospective study in the French Hemophilia Comprehensive Care and Clinical Hemostasis Centers. Women between 15 and 65 years with factor XIII activity &lt;10 IU dL<sup>-1<\/sup> were included. Biological, clinical and therapeutic events that occurred to these patients during their gynecological and obstetrical period were recorded.<\/p>\n<p><strong class=\"sub-title\"> Results: <\/strong> Among 31 centers, eleven patients were included. The median age at diagnosis was 1.5 years (range: 0-35), and at inclusion it was 30 years (range: 15-63). Fetal miscarriage was the primary manifestations in 2 (18%) patients, the remaining were diagnosed during hemorrhage. Menorrhagias were reported by 2 women (27%), 13 pregnancies were reported by 9 women including one abortion. Every pregnancy was conducted under factor XIII substitution, no hemorrhagic episode was reported. Four patients (36%) experienced at least one fetal miscarriage with a total amount of 30 miscarriages with 6 occurring during substitution.<\/p>\n<p><strong class=\"sub-title\"> Conclusion: <\/strong> Altogether, our data confirmed the high incidence of miscarriage in women with factor XIII deficiency. Good outcome of pregnancies required prophylaxis in accordance with international guidelines.<\/p>\n<\/div>\n<p><strong class=\"sub-title\"> Keywords: <\/strong> Factor XIII deficiency; Menorrhagia; Miscarriages; Pregnancy outcome.<\/p>\n<\/div>\n<p id=\"copyright\" class=\"copyright\">Copyright \u00a9 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.<\/p>\n","protected":false},"parent":0,"template":"","keyword":[],"class_list":["post-1047","publications_science","type-publications_science","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Rugeri L et al : Gynecological and obstetric outcome in the French cohort of women with Factor XIII deficiency - FranceCoag<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.francecoag.org\/en\/publications_science\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rugeri L et al : Gynecological and obstetric outcome in the French cohort of women with Factor XIII deficiency - FranceCoag\" \/>\n<meta property=\"og:description\" content=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32360976\/ PMID: 32360976 DOI: 10.1016\/j.thromres.2020.04.010 Abstract Introduction: Congenital factor XIII deficiency is a very rare bleeding disorder affecting 33 patients [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.francecoag.org\/en\/publications_science\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\/\" \/>\n<meta property=\"og:site_name\" content=\"FranceCoag\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-12T14:33:33+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\\\/\",\"url\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\\\/\",\"name\":\"Rugeri L et al : Gynecological and obstetric outcome in the French cohort of women with Factor XIII deficiency - FranceCoag\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#website\"},\"datePublished\":\"2020-12-19T13:40:05+00:00\",\"dateModified\":\"2026-02-12T14:33:33+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Publications scientifiques\",\"item\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/publications_science\\\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Rugeri L et al : Gynecological and obstetric outcome in the French cohort of women with Factor XIII deficiency\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/\",\"name\":\"FranceCoag\",\"description\":\"La cohorte FranceCoag accompagne plus de 10.000 patients atteints d\u2019une maladie h\u00e9morragique\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#organization\",\"name\":\"FranceCoag\",\"url\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.francecoag.org\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/logo-france-COAG-1.png\",\"contentUrl\":\"https:\\\/\\\/www.francecoag.org\\\/wp-content\\\/uploads\\\/2023\\\/12\\\/logo-france-COAG-1.png\",\"width\":600,\"height\":260,\"caption\":\"FranceCoag\"},\"image\":{\"@id\":\"https:\\\/\\\/www.francecoag.org\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rugeri L et al : Gynecological and obstetric outcome in the French cohort of women with Factor XIII deficiency - FranceCoag","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.francecoag.org\/en\/publications_science\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\/","og_locale":"en_US","og_type":"article","og_title":"Rugeri L et al : Gynecological and obstetric outcome in the French cohort of women with Factor XIII deficiency - FranceCoag","og_description":"https:\/\/pubmed.ncbi.nlm.nih.gov\/32360976\/ PMID: 32360976 DOI: 10.1016\/j.thromres.2020.04.010 Abstract Introduction: Congenital factor XIII deficiency is a very rare bleeding disorder affecting 33 patients [&hellip;]","og_url":"https:\/\/www.francecoag.org\/en\/publications_science\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\/","og_site_name":"FranceCoag","article_modified_time":"2026-02-12T14:33:33+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.francecoag.org\/en\/publications_science\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\/","url":"https:\/\/www.francecoag.org\/en\/publications_science\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\/","name":"Rugeri L et al : Gynecological and obstetric outcome in the French cohort of women with Factor XIII deficiency - FranceCoag","isPartOf":{"@id":"https:\/\/www.francecoag.org\/en\/#website"},"datePublished":"2020-12-19T13:40:05+00:00","dateModified":"2026-02-12T14:33:33+00:00","breadcrumb":{"@id":"https:\/\/www.francecoag.org\/en\/publications_science\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.francecoag.org\/en\/publications_science\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.francecoag.org\/en\/publications_science\/rugeri-l-et-al-gynecological-and-obstetric-outcome-in-the-french-cohort-of-women-with-factor-xiii-deficiency\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.francecoag.org\/en\/"},{"@type":"ListItem","position":2,"name":"Publications scientifiques","item":"https:\/\/www.francecoag.org\/en\/publications_science\/"},{"@type":"ListItem","position":3,"name":"Rugeri L et al : Gynecological and obstetric outcome in the French cohort of women with Factor XIII deficiency"}]},{"@type":"WebSite","@id":"https:\/\/www.francecoag.org\/en\/#website","url":"https:\/\/www.francecoag.org\/en\/","name":"FranceCoag","description":"La cohorte FranceCoag accompagne plus de 10.000 patients atteints d\u2019une maladie h\u00e9morragique","publisher":{"@id":"https:\/\/www.francecoag.org\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.francecoag.org\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.francecoag.org\/en\/#organization","name":"FranceCoag","url":"https:\/\/www.francecoag.org\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.francecoag.org\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.francecoag.org\/wp-content\/uploads\/2023\/12\/logo-france-COAG-1.png","contentUrl":"https:\/\/www.francecoag.org\/wp-content\/uploads\/2023\/12\/logo-france-COAG-1.png","width":600,"height":260,"caption":"FranceCoag"},"image":{"@id":"https:\/\/www.francecoag.org\/en\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/publications_science\/1047","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/publications_science"}],"about":[{"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/types\/publications_science"}],"version-history":[{"count":1,"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/publications_science\/1047\/revisions"}],"predecessor-version":[{"id":1048,"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/publications_science\/1047\/revisions\/1048"}],"wp:attachment":[{"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/media?parent=1047"}],"wp:term":[{"taxonomy":"keyword","embeddable":true,"href":"https:\/\/www.francecoag.org\/en\/wp-json\/wp\/v2\/keyword?post=1047"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}